The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?

Dev Cell. 2013 May 13;25(3):225-7. doi: 10.1016/j.devcel.2013.04.019.


We report that the metazoan Wnt protease and signaling inhibitor TIKI shares sequence homology with bacterial TraB/PrgY proteins, inhibitors of pheromone signaling essential for propagation of antibiotic resistance. Our analysis suggests that these proteins represent an ancient metalloprotease clan regulating cellular communications across biological kingdoms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacteria / enzymology*
  • Bacterial Proteins / metabolism*
  • Catalytic Domain
  • Cell Communication
  • Drug Resistance, Bacterial / genetics
  • Metalloproteases / metabolism*
  • Pheromones / antagonists & inhibitors
  • Protein Folding*
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Proteolysis
  • Sequence Homology, Amino Acid
  • Wnt Proteins / metabolism*


  • Bacterial Proteins
  • Pheromones
  • Wnt Proteins
  • traB protein, Bacteria
  • Metalloproteases