Coffee consumption and the risk of prostate cancer: the Ohsaki Cohort Study

Br J Cancer. 2013 Jun 11;108(11):2381-9. doi: 10.1038/bjc.2013.238. Epub 2013 May 14.


Background: Epidemiological evidence regarding the effect of coffee on the incidence of prostate cancer is inconsistent. We aimed to investigate coffee consumption and the risk of prostate cancer risk in a general Japanese population.

Methods: We conducted a prospective cohort study in Ohsaki city, Japan, where 18 853 men aged 40-79 years participated in a baseline survey. Coffee consumption was assessed via a validated self-administered questionnaire. During 11 years of follow-up (from January 1 1995 to December 31, 2005), 318 incident cases of prostate cancer were detected. The Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) and 95% confidence interval (CIs).

Results: There was a significant inverse association between coffee consumption and the incidence risk of prostate cancer. Compared with those who did not drink coffee, the multivariate adjusted HRs were 0.81 (95% CI: 0.61-1.07), 0.73 (95% CI: 0.53-1.00), and 0.63 (095% CI: 0.39-1.00) for those who drank coffee occasionally, 1-2 cups per day, and > or =3 cups per day, respectively, with a P for trend of 0.02.

Conclusion: This prospective finding from a Japanese population adds evidence that coffee intake is inversely associated with the incidence of prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coffee*
  • Cohort Studies
  • Humans
  • Incidence
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Prospective Studies
  • Prostatic Neoplasms / epidemiology*


  • Coffee