Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 6 (275), pe18

A Role for Hipk in the Hippo Pathway

Affiliations
Review

A Role for Hipk in the Hippo Pathway

Emad Heidary Arash et al. Sci Signal.

Abstract

Since characterization of the Hippo pathway as a major regulator of growth control and organ size, major efforts to unravel the molecular mechanisms that regulate this pathway have been undertaken. These investigations have led to the discovery of diverse upstream regulators of Hippo signaling, the majority of which function to activate the Hippo kinase cascade and thereby restrict the transcriptional output of the downstream targets, Yorkie (Yki) in flies and TAZ and YAP in mammals, collectively Yki/TAZ/YAP. Two studies have delineated a role for HIPK (homeodomain-interacting protein kinase) in promoting Yki/TAZ/YAP transcriptional activity.

Similar articles

See all similar articles

Cited by 1 article

  • Effect of YAP Inhibition on Human Leukemia HL-60 Cells.
    Chen M, Wang J, Yao SF, Zhao Y, Liu L, Li LW, Xu T, Gan LG, Xiao CL, Shan ZL, Zhong L, Liu BZ. Chen M, et al. Int J Med Sci. 2017 Jul 20;14(9):902-910. doi: 10.7150/ijms.19965. eCollection 2017. Int J Med Sci. 2017. PMID: 28824329 Free PMC article.

MeSH terms

LinkOut - more resources

Feedback