Posterior capsule opacification with the iMics1 NY-60 and AcrySof SN60WF 1-piece hydrophobic acrylic intraocular lenses: 3-year results of a randomized trial

Am J Ophthalmol. 2013 Aug;156(2):375-381.e2. doi: 10.1016/j.ajo.2013.04.007. Epub 2013 May 13.


Purpose: To compare the intensity of posterior capsule opacification (PCO) 3 years after implantation of 2 different 1-piece foldable hydrophobic acrylic intraocular lenses (IOLs).

Design: Randomized, prospective, patient- and examiner-masked clinical trial with intraindividual comparison.

Methods: One hundred patients with bilateral age-related cataract (200 eyes) had standard cataract surgery with implantation of an iMics1 NY-60 IOL (Hoya Corp) in one eye and an AcrySof SN60WF IOL (Alcon Laboratories) in the other eye. Follow-up examinations were performed at 1 week and 3 years. Digital retroillumination images were obtained of each eye. The main outcome measure was PCO score (scale, 0 to 10) assessed subjectively at the slit lamp and objectively using automated image analysis software (Automated Quantification of After-Cataract) 3 years after surgery.

Results: The objective PCO score (mean ± standard deviation) was 3.0 ± 2.0 for the iMics1 NY-60 IOL and 1.9 ± 1.4 for the AcrySof SN60WF IOL (P < .001). Three years after surgery, 35.6% of patients underwent a neodymium:yttrium-aluminum-garnet capsulotomy in the iMics1 NY-60 eye and 13.7% underwent a capsulotomy in the AcrySof SN60WF eye (P = .001). There was no statistically significant difference in best-corrected visual acuity, rhexis-IOL overlap, capsular folds, or anterior capsule opacification. Glistening formations were found in no iMics1 NY-60 IOLs, but in 97% of the AcrySof SN60WF IOLs.

Conclusions: Comparison of 2 sharp-edged single-piece IOLs of similar design and hydrophobic acrylic material indicated a statistically significant difference in PCO and neodymium:yttrium-aluminum-garnet capsulotomy rate 3 years after surgery.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acrylic Resins*
  • Aged
  • Capsule Opacification / diagnosis
  • Capsule Opacification / etiology*
  • Capsule Opacification / surgery
  • Double-Blind Method
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Laser Therapy
  • Lasers, Solid-State / therapeutic use
  • Lens Implantation, Intraocular*
  • Lenses, Intraocular / adverse effects*
  • Male
  • Phacoemulsification*
  • Posterior Capsule of the Lens / pathology*
  • Prospective Studies
  • Prosthesis Design
  • Visual Acuity / physiology


  • Acrylic Resins