Miller Fisher's syndrome

Semin Neurol. 2012 Nov;32(5):512-6. doi: 10.1055/s-0033-1334470. Epub 2013 May 15.


Miller Fisher's syndrome is a rare variant of Guillain-Barré's syndrome characterized by the acute development of ataxia, ophthalmoparesis, and areflexia. Most patients have a measureable antibody in serum directed against the GQ1b ganglioside. This antibody is also present in the serum of patients with other forms of Guillain-Barré's syndrome who have prominent ataxia or ophthalmoplegia as part of their clinical presentation. Miller Fisher's syndrome generally is self-limited and has an excellent prognosis.

Publication types

  • Review

MeSH terms

  • Ataxia / diagnosis
  • Ataxia / drug therapy
  • Ataxia / immunology
  • Autoantibodies / blood*
  • Gangliosides / immunology*
  • Humans
  • Miller Fisher Syndrome / diagnosis
  • Miller Fisher Syndrome / drug therapy*
  • Miller Fisher Syndrome / immunology
  • Miller Fisher Syndrome / physiopathology
  • Ophthalmoplegia / immunology*
  • Reflex, Abnormal / drug effects*
  • Treatment Outcome


  • Autoantibodies
  • Gangliosides
  • GQ1b ganglioside