The (pro)renin receptor and body fluid homeostasis

Am J Physiol Regul Integr Comp Physiol. 2013 Jul 15;305(2):R104-6. doi: 10.1152/ajpregu.00209.2013. Epub 2013 May 15.


The renin-angiotensin system (RAS) has long been established as one of the major mechanisms of hypertension through the increased levels of angiotensin (ANG) II and its resulting effect on the sympathetic nerve activity, arterial vasoconstriction, water reabsorption, and retention, etc. In the central nervous system, RAS activation affects body fluid homeostasis through increases in sympathetic nerve activity, water intake, food intake, and arginine vasopressin secretion. Previous studies, however, have shown that ANG II can be made in the brain, and it could possibly be through a new component called the (pro)renin receptor. This review intends to summarize the central and peripheral effects of the PRR on body fluid homeostasis.

Keywords: (pro)renin receptor; body fluid homeostasis; renin-angiotensin system.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Pressure / physiology
  • Homeostasis / physiology*
  • Humans
  • Receptors, Cell Surface / physiology*
  • Renin-Angiotensin System / physiology*
  • Sympathetic Nervous System / physiology
  • Water-Electrolyte Balance / physiology*


  • Receptors, Cell Surface
  • prorenin receptor