Serrated adenoma of the stomach: Case report and literature review

World J Gastrointest Endosc. 2013 May 16;5(5):261-4. doi: 10.4253/wjge.v5.i5.261.


Gastric serrated adenomas are histologically characterized by protruding glands with lateral saw tooth-like indentations lined with stratified dysplastic cells containing abundant eosinophilic cytoplasm. Since the first case of gastric serrated adenoma found in 2001, 18 additional cases have been reported. Gastric serrated adenomas have a particular proclivity to progress to invasive carcinoma; 75% or 15 of the 20 cases now in record - including the present one - exhibited invasive carcinoma. The 20(th) case of gastric serrated adenoma reported here differs from the preceding ones in as much as it evolved in a patient with Lynch syndrome, implying that this adenoma phenotype may develop not only sporadically but also in patients with hereditary traits.

Keywords: Gastric; Lynch syndrome; Neoplasia; Serrated.