NSAIDs can have adverse effects on bone healing

Med Hypotheses. 2013 Aug;81(2):343-6. doi: 10.1016/j.mehy.2013.03.042. Epub 2013 May 13.


The science of osteoimmunology, a relatively new field of research, reveals the important interactions between the immune system and skeletal system. Interactions occur between prostaglandin metabolism, inflammatory proteins and bone metabolism. Systemic as well as local sources of inflammation appear to be actively involved in both bone formation and resorption. Non Steroidal Anti-Inflammatory Drugs (NSAIDs) can play a detrimental role in bone fractures, opposing the aim of the intervention, and can have such a negative impact on the synthesis of prostaglandins that they could even promote bone resorption. When used for a prolonged time, NSAIDs can also cause the development of an inflammatory cascade starting from the gastro-intestinal system, possibly resulting in bone resorption. Several studies show that the use of either selective or non-selective NSAIDs are intimately related to disturbances in immunological allostasis, bone metabolism and the inhibition or impediment of bone healing.

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Fracture Healing / drug effects*
  • Humans
  • Models, Theoretical


  • Anti-Inflammatory Agents, Non-Steroidal