Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese

J Affect Disord. 2013 Sep 5;150(2):261-5. doi: 10.1016/j.jad.2013.04.004. Epub 2013 May 13.

Abstract

Background: A growing body of evidence highlights the existence of shared genetic susceptibility to both major depressive disorder (MDD) and bipolar disorder (BD), suggesting some potential genetic overlap between the disorders. Genome-wide association studies have identified consistent association of single nucleotide polymorphisms of the α-1 C subunit of the L-type voltage-gated calcium channel gene (CACNA1C) with MDD and BD, suggesting CACNA1C as a promising candidate gene for susceptibility to mood disorders. In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese.

Methods: We genotyped three potentially functional polymorphisms in 635 MDD patients, 286 BD patients and 730 normal, control patients.

Results: The genotype frequencies of SNP rs1051375 showed statistically significant differences between the BD and control groups (P=0.005). At the allele level, the difference of G allele frequency of rs1051375 between BD patients and control subjects was also significant (P=0.011; OR=1.30, 95% CI: 1.06-1.58). We found that GG genotype of rs1051375 carriers had a lower age at onset than those with the AG or AA genotype, and the mean±standard deviation ages at onset of GG, AG and AA carriers were 24.04±4.22, 25.76±4.75 and 25.78±4.33 years, respectively. Neither genotype nor allele frequencies of the three polymorphisms were found to be significantly different between the MDD patients and control subjects.

Limitations: The relative small sample size in BD group should be considered a limitation of this study.

Conclusions: Our initial findings support a potential association of CACNA1C as a genetic risk factor for BD susceptibility.

Keywords: Age at onset; Bipolar disorder; CACNA1C; Major depressive disorder; Polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Asian Continental Ancestry Group / genetics*
  • Bipolar Disorder / genetics*
  • Bipolar Disorder / physiopathology
  • Calcium Channels, L-Type / genetics*
  • Case-Control Studies
  • Depressive Disorder, Major / genetics*
  • Female
  • Genetic Predisposition to Disease*
  • Genetic Variation
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

Substances

  • CACNA1C protein, human
  • Calcium Channels, L-Type