Ketogenic diets and pain

J Child Neurol. 2013 Aug;28(8):993-1001. doi: 10.1177/0883073813487595. Epub 2013 May 16.


Ketogenic diets are well established as a successful anticonvulsant therapy. Based on overlap between mechanisms postulated to underlie pain and inflammation, and mechanisms postulated to underlie therapeutic effects of ketogenic diets, recent studies have explored the ability for ketogenic diets to reduce pain. Here we review clinical and basic research thus far exploring the impact of a ketogenic diet on thermal pain, inflammation, and neuropathic pain.

Keywords: Taxol; chronic constriction injury; glucose; hypoalgesia; inflammation; ketones; metabolismc; neuropathic pain.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Diet, Ketogenic / methods*
  • Humans
  • Inflammation / diet therapy
  • Inflammation / metabolism
  • Ketones / metabolism
  • Pain / complications
  • Pain / diet therapy*
  • Pain / etiology
  • Pain Threshold / physiology
  • Physical Stimulation
  • Rats


  • Ketones