Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids

JAMA Dermatol. 2013 Mar;149(3):350-5. doi: 10.1001/jamadermatol.2013.1495.


Objective: To identify whether nutrient supplementation with probiotics, prebiotics, formula, or fatty acids prevents the development of atopic dermatitis (AD) or reduces the severity of AD in newborns to children younger than 3 years.

Data sources: We searched MEDLINE, Cochrane Central Register of Controlled Trials, and LILACS (Latin American and Caribbean Health Science Literature) from January 1, 1946, to August 27, 2012, and performed an additional manual search.

Study selection: Randomized controlled trials and cohort studies examining nutritional supplementation in prevention and amelioration of AD among children younger than 3 years.

Data extraction: Of 92 articles, 21 met inclusion criteria.

Data synthesis: In the 21 studies, a total of 6859 participants received supplements, which included infants or mothers who were either pregnant or breastfeeding;4134 infants or mothers served as controls. Nutritional supplementation was shown to be an effective method in preventing AD (11 of 17 studies) or decreasing its severity(5 of 6 studies). The best evidence lies with probiotics supplementation in mothers and infants in preventing development and reducing severity of AD. Specifically, Lactobacillus rhamnosus GG was effective in long-term prevention of AD development. γ-Linolenic acid reduced severity of AD. Supplementation with prebiotics and black currant seed oil (γ-linolenic acid and ω-3 combination) was effective in reducing the development of AD. Conflicting findings were reported from different research groups that performed supplementation with an amino acid–based formula.

Conclusions: Certain types of nutrient supplementation are beneficial in preventing AD development and reducing its severity. Future research elucidating the mechanisms underlying the actions of nutritional supplementation on AD is necessary.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Amino Acids / administration & dosage
  • Breast Feeding
  • Child, Preschool
  • Dermatitis, Atopic / pathology
  • Dermatitis, Atopic / prevention & control
  • Dermatitis, Atopic / therapy*
  • Dietary Supplements*
  • Fatty Acids / therapeutic use
  • Female
  • Humans
  • Infant
  • Infant Formula / administration & dosage
  • Infant Formula / chemistry
  • Infant, Newborn
  • Lacticaseibacillus rhamnosus
  • Prebiotics*
  • Pregnancy
  • Probiotics / therapeutic use*
  • Severity of Illness Index


  • Amino Acids
  • Fatty Acids
  • Prebiotics