Pharmacokinetics of linezolid in the mediastinum and pleural space

Abstract

The purpose of this study was to investigate the penetration of linezolid into the mediastinum and pleural space by comparing its concentration in the serum, mediastinum, and pleural space. The linezolid area under the concentration-versus-time curve from zero to 12h (AUC)(mediastinum fluid/serum) and AUC(pleural fluid/serum) ratio were 1.32 and 1.64, respectively. The results suggest that the linezolid concentration in the mediastinum varies as in the serum, and that the concentration in the mediastinum is the same as or greater than that in the serum.

Keywords: Cardiovascular surgery; Linezolid; Mediastinitis; Penetration to mediastinum; Pharmacokinetics.