Non-coding RNAs in DNA damage and repair

FEBS Lett. 2013 Jun 27;587(13):1832-9. doi: 10.1016/j.febslet.2013.05.006. Epub 2013 May 16.

Abstract

Non-coding RNAs (ncRNAs) are increasingly recognized as central players in diverse biological processes. Upon DNA damage, the DNA damage response (DDR) elicits a complex signaling cascade, which includes the induction of multiple ncRNA species. Recent studies indicate that DNA-damage induced ncRNAs contribute to regulation of cell cycle, apoptosis and DNA repair, and thus play a key role in maintaining genome stability. This review summarizes the emerging role of ncRNAs in DNA damage and repair.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Damage*
  • DNA Repair Enzymes / genetics
  • DNA Repair Enzymes / metabolism
  • DNA Repair*
  • Gene Expression
  • Gene Expression Regulation
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Protein Processing, Post-Translational
  • RNA, Untranslated / physiology*
  • Signal Transduction

Substances

  • Intracellular Signaling Peptides and Proteins
  • RNA, Untranslated
  • DNA Repair Enzymes