Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert

Fitoterapia. 2013 Sep;89:167-74. doi: 10.1016/j.fitote.2013.05.008. Epub 2013 May 15.

Abstract

Five new phenylethanoid glycosides, cistanosides J-N (1-5), together with 15 known ones (6-20) were isolated from the stems of Cistanche deserticola cultured in Tarim desert, China. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR) and chemical degradation. All the compounds obtained were examined for their inhibitory effect on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse microglial cells (BV-2 cells), and compounds 2 and 8 showed potent inhibition on the NO production with IC50 values of 14.94 μM and 14.32 μM, respectively.

Keywords: Anti-inflammatory activity; Cistanche deserticola; Cistanoside; Phenylethanoid glycoside.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • China
  • Cistanche / chemistry*
  • Ecosystem
  • Glucosides / chemistry
  • Glucosides / isolation & purification
  • Glucosides / pharmacology*
  • Glycosides / chemistry
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Inflammation / drug therapy
  • Inflammation / metabolism*
  • Inhibitory Concentration 50
  • Lipopolysaccharides
  • Mice
  • Microglia / drug effects
  • Microglia / metabolism
  • Molecular Structure
  • Nitric Oxide / biosynthesis*
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Stems / chemistry

Substances

  • Anti-Inflammatory Agents
  • Glucosides
  • Glycosides
  • Lipopolysaccharides
  • Plant Extracts
  • cistanoside K
  • tubuloside B
  • Nitric Oxide