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Case Reports
. 2013 Jul;117(1):61-4.
doi: 10.1213/ANE.0b013e318292cbd0. Epub 2013 May 17.

Case Report: Profound Hypotension After Anesthetic Induction With Propofol in Patients Treated With Rifampin

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Case Reports

Case Report: Profound Hypotension After Anesthetic Induction With Propofol in Patients Treated With Rifampin

Hooman Mirzakhani et al. Anesth Analg. .

Abstract

Rifampin is commonly used for the treatment of tuberculosis and staphylococcal infections, as well as for prevention of infection in cardiac valve and bone surgeries. We report a case of profound hypotension after anesthesia induction with propofol in a patient who was treated with two 600 mg doses of rifampin for prophylaxis of infection before surgery. In a retrospective case-control study of 75 patients, we confirmed this potentially serious drug-drug interaction. After rifampin, there was a significant and prolonged arterial blood pressure reduction when patients received propofol, but not thiopental.

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