Sub-10 nm Fe3O4@Cu(2-x)S core-shell nanoparticles for dual-modal imaging and photothermal therapy

J Am Chem Soc. 2013 Jun 12;135(23):8571-7. doi: 10.1021/ja4013497. Epub 2013 May 30.


Photothermal nanomaterials have recently attracted significant research interest due to their potential applications in biological imaging and therapeutics. However, the development of small-sized photothermal nanomaterials with high thermal stability remains a formidable challenge. Here, we report the rational design and synthesis of ultrasmall (<10 nm) Fe3O4@Cu2-xS core-shell nanoparticles, which offer both high photothermal stability and superparamagnetic properties. Specifically, these core-shell nanoparticles have proven effective as probes for T2-weighted magnetic resonance imaging and infrared thermal imaging because of their strong absorption at the near-infrared region centered around 960 nm. Importantly, the photothermal effect of the nanoparticles can be precisely controlled by varying the Cu content in the core-shell structure. Furthermore, we demonstrate in vitro and in vivo photothermal ablation of cancer cells using these multifunctional nanoparticles. The results should provide improved understanding of synergistic effect resulting from the integration of magnetism with photothermal phenomenon, important for developing multimode nanoparticle probes for biomedical applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media* / chemistry
  • Contrast Media* / therapeutic use
  • Copper* / chemistry
  • Copper* / therapeutic use
  • Ferric Compounds* / chemistry
  • Ferric Compounds* / therapeutic use
  • HeLa Cells
  • Humans
  • Magnetic Phenomena
  • Magnetic Resonance Imaging*
  • Mice
  • Nanoparticles* / chemistry
  • Nanoparticles* / therapeutic use
  • Neoplasms / diagnosis*
  • Neoplasms / drug therapy
  • Particle Size
  • Phototherapy*
  • Surface Properties


  • Contrast Media
  • Ferric Compounds
  • ferric oxide
  • Copper
  • cupric sulfide