The second generation of iodido complexes: trans-[PtI2(amine)(amine')] bearing different aliphatic amines

J Inorg Biochem. 2013 Oct;127:182-7. doi: 10.1016/j.jinorgbio.2013.04.010. Epub 2013 Apr 28.

Abstract

The antitumoral potential for a series of platinum iodido complexes, all bearing the same aliphatic amines (first iodido complexes generation), was demonstrated in a previous study. Concretely, cis complexes were shown to have a peculiar and different reactivity compared to cisplatin with sulfur donors models and Cyt C. In this work we have synthesized and studied iodido complexes bearing different aliphatic amines in trans configuration (the second generation) to investigate their potential antitumor activity in a panel of cell lines. Their interaction with biological models such as pBR322 and smaller biomolecules (5'-GMP, 9EtG, N-AcMet and N-AcCys) have been studied and compared to cisplatin and to the first iodido series. Their cytotoxicity, on the other hand, turned out to be especially active towards cell lines where cisplatin has no effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Amines / pharmacology
  • Antineoplastic Agents* / chemical synthesis
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cisplatin / chemistry
  • Cisplatin / pharmacology
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacology
  • Electrophoresis, Agar Gel
  • Humans
  • Inhibitory Concentration 50
  • Iodine / chemistry*
  • Molecular Structure
  • Platinum / chemistry*

Substances

  • Amines
  • Antineoplastic Agents
  • Coordination Complexes
  • Platinum
  • Iodine
  • Cisplatin