Abstract
South Korean isolates of oseltamivir-resistant influenza viruses from 2005-2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008-2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.
MeSH terms
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Antiviral Agents / pharmacology*
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Drug Resistance, Viral*
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Humans
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Influenza A Virus, H1N1 Subtype / drug effects
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Influenza A Virus, H1N1 Subtype / genetics
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Influenza A Virus, H1N1 Subtype / isolation & purification
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Influenza A Virus, H3N2 Subtype / drug effects
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Influenza A Virus, H3N2 Subtype / genetics
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Influenza A Virus, H3N2 Subtype / isolation & purification
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Influenza B virus / drug effects
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Influenza B virus / genetics
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Influenza B virus / isolation & purification
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Influenza, Human / epidemiology*
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Influenza, Human / virology*
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Mutation
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Neuraminidase / genetics*
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Orthomyxoviridae / classification
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Orthomyxoviridae / drug effects*
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Orthomyxoviridae / genetics
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Orthomyxoviridae / isolation & purification*
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Oseltamivir / pharmacology*
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Phylogeny
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Republic of Korea / epidemiology
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Viral Proteins / genetics
Substances
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Antiviral Agents
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Viral Proteins
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Oseltamivir
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Neuraminidase