Abstract
Two organoantimony (III) derivatives, i.e., diphenylantimony diphenyl-dithiophosphinate, Ph2SbS2PPh2, and diphenylantimony diizopropyldithiophosphate, Ph2SbS2P(OPri)2, were shown to exhibit antitumor properties. Both compounds produced strong tumor inhibition effects in mice bearing Ehrlich ascites tumor. Moreover, the dithiophosphate (15 mg/kg, i.p., in days 1, 3 and 5) produced a cure rate of 30%.
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use*
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Carcinoma, Ehrlich Tumor / drug therapy*
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Drug Evaluation, Preclinical
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Male
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Mice
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Organometallic Compounds / therapeutic use*
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Organothiophosphorus Compounds / therapeutic use*
Substances
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Antineoplastic Agents
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Organometallic Compounds
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Organothiophosphorus Compounds
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diphenylantimony diphenyldithiophosphinate
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diphenylantimony diisopropyldithiophosphate