Compliance declines between clinic visits

Arch Intern Med. 1990 Jul;150(7):1509-10.


Adherence to prescribed drug dosing regimens declined substantially during the interval between clinic visits and drug level tests. Using microelectronic monitors to observe pill-taking habits, 20 patients averaged 88% compliance before and 86% compliance after the visit, but this dropped to 67% compliance a month later. These data indicate that spot drug levels do not represent long-term "steady-state" drug serum concentrations.

MeSH terms

  • Anticonvulsants / administration & dosage*
  • Anticonvulsants / blood
  • Drug Administration Schedule
  • Drug Packaging / methods
  • Electronic Data Processing
  • Humans
  • Monitoring, Physiologic
  • Office Visits*
  • Patient Compliance*
  • Seizures / drug therapy*


  • Anticonvulsants