Association between waking electroencephalography and cognitive event-related potentials in patients with obstructive sleep apnea

Abstract

Objective: Sleepiness, cognitive deficits, abnormal event-related potentials (ERP), and slowing of the waking electroencephalography (EEG) activity have been reported in patients with obstructive sleep apnea (OSA). Our study aimed at evaluating if an association exists between the severity of ERP abnormalities and EEG slowing to better understand cerebral dysfunctions in OSA.

Methods: Twelve OSA patients and 12 age-matched controls underwent an overnight polysomnographic recording, an EEG recording of 10 min of wakefulness, and an auditory ERP protocol known to specifically recruit attention. P300 and P3a ERP components were measured as well as the spectral power in each frequency band of the waking EEG. Pearson product moment correlations were used to measure associations between ERP characteristics and EEG spectral power in OSA patients and control subjects.

Results: A positive correlation between the late P300 amplitude and θ power in the occipital region was observed in OSA subjects (P<.01). A positive correlation was also found between P3a amplitude and β1 power in central region in OSA subjects (P<.01). No correlation was observed for control subjects.

Conclusions: ERP abnormalities observed in an attention task are associated with a slowing of the waking EEG recorded at rest in OSA.

Keywords: Attention; Cognition; Event-related potentials; Obstructive sleep apnea; P300; P3a; Quantitative electroencephalography; Vigilance.