A prospective investigation of fish, meat and cooking-related carcinogens with endometrial cancer incidence

Br J Cancer. 2013 Aug 6;109(3):756-60. doi: 10.1038/bjc.2013.252. Epub 2013 May 21.


Background: There are limited prospective studies of fish and meat intakes with risk of endometrial cancer and findings are inconsistent.

Methods: We studied associations between fish and meat intakes and endometrial cancer incidence in the large, prospective National Institutes of Health-AARP Diet and Health Study. Intakes of meat mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and benzo(a)pyrene (BaP) were also calculated. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results: We observed no associations with endometrial cancer risk comparing the highest to lowest intake quintiles of red (HR=0.91, 95% CI 0.77-1.08), white (0.98, 0.83-1.17), processed meats (1.02, 0.86-1.21) and fish (1.10, 95% CI 0.93-1.29). We also found no associations between meat mutagen intakes and endometrial cancer.

Conclusion: Our findings do not support an association between meat or fish intakes or meat mutagens and endometrial cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • Cooking / statistics & numerical data*
  • Diet / statistics & numerical data*
  • Endometrial Neoplasms / epidemiology*
  • Endometrial Neoplasms / etiology
  • Female
  • Fishes*
  • Follow-Up Studies
  • Humans
  • Meat / statistics & numerical data*
  • Middle Aged
  • United States / epidemiology