Safety assessment of 2-amino-4-hydroxyethylaminoanisole and 2-amino-4-hydroxyethylaminoanisole sulfate as used in cosmetics

Int J Toxicol. May-Jun 2013;32(3 Suppl):25S-35S. doi: 10.1177/1091581813486301.


2-Amino-4-hydroxyethylaminoanisole and its salt, 2-amino-4-hydroxyethylaminoanisole sulfate, are used as coupling agents in oxidative hair dyes. The Cosmetic Ingredient Review Expert Panel reviewed relevant animal and human data related to the ingredient. The Expert Panel concluded that 2-amino-4-hydroxyethylaminoanisole and 2-amino-4-hydroxyethylaminoanisole sulfate are safe for use in oxidative hair dye formulations. The Expert Panel cautioned that these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed.

Keywords: 2-amino-4-hydroxyethylaminoanisole.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Consumer Product Safety*
  • Cosmetics / chemistry
  • Cosmetics / pharmacokinetics
  • Cosmetics / toxicity*
  • Humans
  • Molecular Structure
  • Phenylenediamines / chemistry
  • Phenylenediamines / pharmacokinetics
  • Phenylenediamines / toxicity*
  • Risk Assessment
  • Toxicity Tests / methods


  • Cosmetics
  • Phenylenediamines
  • 2-amino-4-hydroxyethylaminoanisole