Safety assessment of silylates and surface-modified siloxysilicates

Int J Toxicol. May-Jun 2013;32(3 Suppl):5S-24S. doi: 10.1177/1091581813486299.

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate as used in cosmetics. These silylates and surface-modified siloxysilicates function in cosmetics as antifoaming agents, anticaking agents, bulking agents, binders, skin-conditioning agents--emollient, skin-conditioning agents-occlusive, slip modifiers, suspension agents--nonsurfactant, and viscosity increasing agents--nonaqueous. The Expert Panel reviewed the available animal and clinical data as well as information from a previous CIR safety assessment of amorphous silica. The CIR Expert Panel concluded that silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate are safe as used when formulated and delivered in the final product not to be irritating or sensitizing to the respiratory tract.

Keywords: silylates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Consumer Product Safety*
  • Cosmetics / administration & dosage
  • Cosmetics / chemistry
  • Cosmetics / toxicity*
  • Humans
  • Hydrocarbons, Fluorinated / administration & dosage
  • Hydrocarbons, Fluorinated / chemistry
  • Hydrocarbons, Fluorinated / pharmacokinetics
  • Hydrocarbons, Fluorinated / toxicity*
  • Molecular Structure
  • Organosilicon Compounds / administration & dosage
  • Organosilicon Compounds / chemistry
  • Organosilicon Compounds / pharmacokinetics
  • Organosilicon Compounds / toxicity*
  • Silicon Dioxide / administration & dosage
  • Silicon Dioxide / chemistry
  • Silicon Dioxide / pharmacokinetics
  • Silicon Dioxide / toxicity*
  • Silicone Oils / administration & dosage
  • Silicone Oils / chemistry
  • Silicone Oils / pharmacokinetics
  • Silicone Oils / toxicity
  • Surface Properties
  • Toxicity Tests / methods
  • Trimethylsilyl Compounds / administration & dosage
  • Trimethylsilyl Compounds / chemistry
  • Trimethylsilyl Compounds / pharmacokinetics
  • Trimethylsilyl Compounds / toxicity

Substances

  • Antifoam A
  • Cosmetics
  • Hydrocarbons, Fluorinated
  • Organosilicon Compounds
  • Silicone Oils
  • Trimethylsilyl Compounds
  • Silicon Dioxide