Abstract
The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate as used in cosmetics. These silylates and surface-modified siloxysilicates function in cosmetics as antifoaming agents, anticaking agents, bulking agents, binders, skin-conditioning agents--emollient, skin-conditioning agents-occlusive, slip modifiers, suspension agents--nonsurfactant, and viscosity increasing agents--nonaqueous. The Expert Panel reviewed the available animal and clinical data as well as information from a previous CIR safety assessment of amorphous silica. The CIR Expert Panel concluded that silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate are safe as used when formulated and delivered in the final product not to be irritating or sensitizing to the respiratory tract.
Keywords:
silylates.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Consumer Product Safety*
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Cosmetics / administration & dosage
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Cosmetics / chemistry
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Cosmetics / toxicity*
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Humans
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Hydrocarbons, Fluorinated / administration & dosage
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Hydrocarbons, Fluorinated / chemistry
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Hydrocarbons, Fluorinated / pharmacokinetics
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Hydrocarbons, Fluorinated / toxicity*
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Molecular Structure
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Organosilicon Compounds / administration & dosage
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Organosilicon Compounds / chemistry
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Organosilicon Compounds / pharmacokinetics
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Organosilicon Compounds / toxicity*
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Silicon Dioxide / administration & dosage
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Silicon Dioxide / chemistry
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Silicon Dioxide / pharmacokinetics
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Silicon Dioxide / toxicity*
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Silicone Oils / administration & dosage
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Silicone Oils / chemistry
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Silicone Oils / pharmacokinetics
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Silicone Oils / toxicity
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Surface Properties
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Toxicity Tests / methods
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Trimethylsilyl Compounds / administration & dosage
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Trimethylsilyl Compounds / chemistry
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Trimethylsilyl Compounds / pharmacokinetics
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Trimethylsilyl Compounds / toxicity
Substances
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Antifoam A
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Cosmetics
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Hydrocarbons, Fluorinated
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Organosilicon Compounds
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Silicone Oils
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Trimethylsilyl Compounds
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Silicon Dioxide