[Paclitaxel induced apoptotic genes and pathways alterations: a review]

Sheng Wu Gong Cheng Xue Bao. 2013 Feb;29(2):153-60.
[Article in Chinese]

Abstract

Taxol has clinical efficacy on many malignant tumors, thus having a good market prospects. The anti-cancer mechanism of taxol is to arrest the cell cycle of tumor cells, leading to apoptosis. Based on our research over the years, we reviewed the latest developments in signaling pathways, the effects of related genes and proteins on apoptosis during paclitaxel-induced apoptosis process, including the paclitaxel-producing gene in microbial fermentation process, cyclin, telomerase of apoptosis.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Apoptosis / drug effects*
  • Apoptosis / genetics
  • Cell Cycle Checkpoints / drug effects
  • Humans
  • MAP Kinase Signaling System / drug effects
  • NF-kappa B / metabolism
  • Neoplasms / drug therapy
  • Neoplasms / pathology*
  • Paclitaxel / pharmacology*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Signal Transduction*
  • p38 Mitogen-Activated Protein Kinases / metabolism

Substances

  • Antineoplastic Agents, Phytogenic
  • NF-kappa B
  • Phosphatidylinositol 3-Kinases
  • p38 Mitogen-Activated Protein Kinases
  • Paclitaxel