Trisomy 7, trisomy 10, and loss of the Y chromosome in short-term cultures of normal kidney tissue

Cytogenet Cell Genet. 1990;53(2-3):123-5. doi: 10.1159/000132910.


Numerical chromosome aberrations are common in several types of malignant tumors. Recently, trisomy 7 and loss of the Y chromosome were described in cultures from nonneoplastic tissue, making the significance of these aberrations as cancer-associated changes doubtful. We herein report the mosaic occurrence of trisomy 7 in four consecutive short-term cultures initiated from normal kidney tissue. Smaller clones with trisomy 10 were present in three cases, and the only culture established from a male also showed mosaic loss of the Y chromosome.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor
  • Cells, Cultured
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 10*
  • Chromosomes, Human, Pair 7*
  • Female
  • Humans
  • Karyotyping
  • Kidney / cytology
  • Male
  • Trisomy*
  • Y Chromosome*


  • Biomarkers, Tumor