Ribonucleoprotein complexes that control circadian clocks

Int J Mol Sci. 2013 Apr 25;14(5):9018-36. doi: 10.3390/ijms14059018.


Circadian clocks are internal molecular time-keeping mechanisms that enable organisms to adjust their physiology and behavior to the daily surroundings. Misalignment of circadian clocks leads to both physiological and health impairment. Post-transcriptional regulation and translational regulation of circadian clocks have been extensively investigated. In addition, accumulating evidence has shed new light on the involvement of ribonucleoprotein complexes (RNPs) in the post-transcriptional regulation of circadian clocks. Numerous RNA-binding proteins (RBPs) and RNPs have been implicated in the post-transcriptional modification of circadian clock proteins in different model organisms. Herein, we summarize the advances in the current knowledge on the role of RNP complexes in circadian clock regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / genetics
  • Alternative Splicing / genetics
  • Animals
  • Circadian Clocks* / genetics
  • Humans
  • Multiprotein Complexes / metabolism*
  • Polyadenylation / genetics
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Ribonucleoproteins / metabolism*


  • Multiprotein Complexes
  • RNA, Messenger
  • Ribonucleoproteins