Abstract
Chemical investigation of the seeds of Croton tiglium afforded eight new phorbol diesters (three phorbol diesters, 1-3, and five 4-deoxy-4α-phorbol diesters, 4-8), together with 11 known phorbol diesters (nine phorbol diesters, 9-17, and two 4-deoxy-4α-phorbol diesters, 18 and 19). The structures of compounds 1-8 were determined by spectroscopic data information and chemical degradation experiments. The cytotoxic activities of the phorbol diesters were evaluated against the SNU387 hepatic tumor cell line, and compound 3 exhibited the most potent activity (IC50 1.2 μM).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology*
-
Croton / chemistry*
-
Drug Screening Assays, Antitumor
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology*
-
Humans
-
Inhibitory Concentration 50
-
Liver Neoplasms / drug therapy
-
Molecular Structure
-
Phorbol Esters / chemistry
-
Phorbol Esters / isolation & purification*
-
Phorbol Esters / pharmacology*
-
Seeds / chemistry
Substances
-
13-O-acetylphorbol-20-oleate
-
Antineoplastic Agents
-
Drugs, Chinese Herbal
-
Phorbol Esters