New concepts in diabetic embryopathy

Clin Lab Med. 2013 Jun;33(2):207-33. doi: 10.1016/j.cll.2013.03.017. Epub 2013 Apr 19.


Diabetes mellitus is responsible for nearly 10% of fetal anomalies in diabetic pregnancies. Although aggressive perinatal care and glycemic control are available in developed countries, the birth defect rate in diabetic pregnancies remains higher than that in the general population. Major cellular activities (ie, proliferation and apoptosis) and intracellular metabolic conditions (ie, nitrosative, oxidative, and endoplasmic reticulum stress) have been shown to be associated with diabetic embryopathy using animal models. Translating advances made in animal studies into clinical applications in humans requires collaborative efforts across the basic research, preclinical, and clinical communities.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Diabetes Mellitus, Experimental
  • Embryo, Mammalian
  • Female
  • Fetal Diseases*
  • Humans
  • Hyperglycemia*
  • Mice
  • Pregnancy
  • Pregnancy in Diabetics*