PERIOSTIN: role in formation and maintenance of dental tissues

J Cell Physiol. 2014 Jan;229(1):1-5. doi: 10.1002/jcp.24407.


The matricellular protein periostin is strongly expressed in collagen-rich connective tissues such as periodontal ligaments (PDLs), skeletal muscle, adipose tissue, tendons, skin, and bone. It is prominent in tumorigenesis, angiogenesis, and cardiac repair. It is localized in the periosteum and PDL, where it is seen in the cytoplasmic extensions of the PDL fibroblasts. It plays a key role in morphogenesis, postnatal development, and maintenance of the tooth, and related structures. It mediates and augments collagen fibrillogenesis, cell migration, adhesion, response to mechanical stress, and wound healing. It has been shown to be an integral regulator of periodontal disease pathogenesis and repair. This review focuses on the various functional aspects of periostin in dental connective tissue development and maintenance.

Publication types

  • Review

MeSH terms

  • Bone Development / genetics
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / metabolism*
  • Cell Movement
  • Collagen / metabolism
  • Connective Tissue / metabolism
  • Fibroblasts / metabolism*
  • Humans
  • Periodontal Ligament / metabolism*
  • Periosteum / metabolism
  • Periosteum / ultrastructure
  • Stress, Mechanical
  • Tooth / growth & development
  • Tooth / metabolism*


  • Cell Adhesion Molecules
  • POSTN protein, human
  • Collagen