Next generation therapeutics for Alzheimer's disease

EMBO Mol Med. 2013 Jun;5(6):795-8. doi: 10.1002/emmm.201202307. Epub 2013 May 23.

Abstract

To date, no truly effective therapy has been developed for Alzheimer's disease or mild cognitive impairment. In searching for new approaches that may succeed where previous ones have failed, it may be instructive to consider the successful therapeutic developments for other chronic illnesses such as cancer and human immunodeficiency virus.

MeSH terms

  • Aging
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Alzheimer Disease / therapy*
  • Amyloid beta-Peptides / antagonists & inhibitors
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Apolipoprotein E4 / genetics
  • Apolipoprotein E4 / metabolism
  • Humans
  • Mice
  • Vitamin D / metabolism

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Apolipoprotein E4
  • Vitamin D