Retinopathy in youth with type 2 diabetes participating in the TODAY clinical trial

Diabetes Care. 2013 Jun;36(6):1772-4. doi: 10.2337/dc12-2387.

Abstract

Objective: To determine the prevalence of retinopathy in 517 youth with type 2 diabetes of 2-8 years duration enrolled in the TODAY study.

Research design and methods: Retinal photographs were graded centrally for retinopathy using established standards.

Results: Retinopathy was identified in 13.7% of subjects. Prevalence increased with age, diabetes duration, and mean HbA1c. Subjects in the highest BMI tertile had the lowest prevalence of retinopathy.

Conclusions: Prevalence of retinopathy and its association with HbA1c and diabetes duration is similar to that previously reported in youth with type 1 diabetes and in adults with type 2 diabetes of known duration. The mechanism underlying the reduced risk of retinopathy in the most obese individuals is unknown. Follow-up of this cohort will help define the natural history of retinopathy in youth with type 2 diabetes.

Trial registration: ClinicalTrials.gov NCT00081328.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Child
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Retinopathy / epidemiology*
  • Diabetic Retinopathy / metabolism
  • Female
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Male
  • Retinal Diseases / metabolism

Substances

  • Glycated Hemoglobin A

Associated data

  • ClinicalTrials.gov/NCT00081328

Grant support