Papillomavirus transcripts and posttranscriptional regulation

Virology. 2013 Oct;445(1-2):187-96. doi: 10.1016/j.virol.2013.04.034. Epub 2013 May 23.


Papillomavirus gene expression is strictly linked to the differentiation state of the infected cell and is highly regulated at the level of transcription and RNA processing. All papillomaviruses make extensive use of alternative mRNA polyadenylation and splicing to control gene expression. This chapter contains a compilation of all known alternatively spliced papillomavirus mRNAs and it summarizes our current knowledge of viral RNA elements, and viral and cellular factors that control papillomavirus mRNA processing.

Keywords: HPV; Papillomavirus; Polyadenylation; SR protein; SRSF1; Splicing; hnRNP; mRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 3' Untranslated Regions
  • Gene Expression Regulation, Viral
  • Humans
  • Keratinocytes / virology
  • Papillomaviridae / genetics
  • Papillomaviridae / metabolism*
  • Polyadenylation*
  • Protein Binding
  • Protein Biosynthesis
  • RNA Splice Sites
  • RNA Splicing*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • RNA, Viral / genetics
  • RNA, Viral / metabolism*
  • Regulatory Sequences, Ribonucleic Acid
  • Transcription, Genetic


  • 3' Untranslated Regions
  • RNA Splice Sites
  • RNA, Messenger
  • RNA, Viral
  • Regulatory Sequences, Ribonucleic Acid