iPOP goes the world: integrated personalized Omics profiling and the road toward improved health care

Chem Biol. 2013 May 23;20(5):660-6. doi: 10.1016/j.chembiol.2013.05.001.


The health of an individual depends upon their DNA as well as upon environmental factors (environome or exposome). It is expected that although the genome is the blueprint of an individual, its analysis with that of the other omes such as the DNA methylome, the transcriptome, proteome, and metabolome will further provide a dynamic assessment of the physiology and health state of an individual. This review will help to categorize the current progress of omics analyses and how omics integration can be used for medical research. We believe that integrative personal omics profiling (iPOP) is a stepping stone to a new road to personalized health care and may improve disease risk assessment, accuracy of diagnosis, disease monitoring, targeted treatments, and understanding the biological processes of disease states for their prevention.

Publication types

  • Review

MeSH terms

  • Animals
  • Computational Biology / methods*
  • DNA / genetics
  • Humans
  • Neoplasms / genetics
  • Precision Medicine / methods*
  • Proteome / genetics
  • RNA / genetics


  • Proteome
  • RNA
  • DNA