Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer

Rev Esp Med Nucl Imagen Mol. 2014 Jan-Feb;33(1):1-5. doi: 10.1016/j.remn.2013.03.005. Epub 2013 May 23.


Aim: To assess dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose (18)(F)FDG PET-CT accuracy in nodal staging and in detection of extra-axillary involvement.

Material and methods: Dual time point [(18)F] FDG PET/CT scan was performed in 75 patients. Visual and semiquantitative assessment of lymph nodes was performed. Semiquantitative measurement of SUV and ROC-analysis were carried out to calculate SUV(max) cut-off value with the best diagnostic performance. Axillary and extra-axillary lymph node chains were evaluated.

Results: Sensitivity and specificity of visual assessment was 87.3% and 75%, respectively. SUV(max) values with the best sensitivity were 0.90 and 0.95 for early and delayed PET, respectively. SUV(max) values with the best specificity were 1.95 and 2.75, respectively. Extra-axillary lymph node involvement was detected in 26.7%.

Conclusion: FDG PET/CT detected extra-axillary lymph node involvement in one-fourth of the patients. Semiquantitative lymph node analysis did not show any advantage over the visual evaluation.

Keywords: (18)(F)FDG PET/CT; Cáncer de mama localmente avanzado; Dual time point PET; Estadificación ganglionar; Locally advanced breast cancer; Lymph node staging; PET en doble fase; [(18)F] FDG PET-TC.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Axilla
  • Biopsy, Fine-Needle
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / pathology
  • Carcinoma, Ductal, Breast / diagnostic imaging
  • Carcinoma, Ductal, Breast / pathology
  • Carcinoma, Ductal, Breast / secondary*
  • Female
  • Fluorine Radioisotopes*
  • Fluorodeoxyglucose F18*
  • Humans
  • Lymphatic Metastasis / diagnostic imaging*
  • Middle Aged
  • Multimodal Imaging / methods*
  • Neoplasm Staging / methods*
  • Positron-Emission Tomography / methods*
  • Predictive Value of Tests
  • Prospective Studies
  • ROC Curve
  • Radiopharmaceuticals*
  • Sensitivity and Specificity
  • Sentinel Lymph Node Biopsy
  • Thorax
  • Tomography, X-Ray Computed / methods*


  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18