Interpretation and management of hepatic abnormalities in pregnancy

Clin Gastroenterol Hepatol. 2013 Nov;11(11):1392-8. doi: 10.1016/j.cgh.2013.05.016. Epub 2013 May 23.


The spectrum of liver disease in pregnancy includes liver disease unrelated to pregnancy, liver diseases that occur with increased frequency or severity in pregnancy, and liver disease specific to pregnancy. Diseases of the liver unique to pregnancy reliably occur at specific points in the gestational spectrum. Thus, gestational age, a comprehensive history, and a clinically driven diagnostic evaluation is critical in approaching a pregnant patient with abnormal liver chemistries or function. Early recognition of these conditions is important and although management may be expectant, some patients require targeted therapy or necessitate prompt delivery, which can be life-saving to both mother and child.

Keywords: AFLOP; Acute Fatty Liver of Pregnancy; HCV; HELLP; HELLP Syndrome; HG; ICP; Intrahepatic Cholestasis of Pregnancy; SBA; UDCA; acute fatty liver of pregnancy; hepatitis C virus; hyperemesis gravidarum; intrahepatic cholestasis of pregnancy; serum bile acid; syndrome of hemolysis, increased liver enzymes, and low platelets; ursodeoxycholic acid.

Publication types

  • Review

MeSH terms

  • Delivery, Obstetric
  • Early Diagnosis
  • Female
  • Humans
  • Liver Diseases / diagnosis*
  • Liver Diseases / therapy*
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Pregnancy Complications / therapy*