Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

Neurobiol Learn Mem. 2013 Oct;105:93-9. doi: 10.1016/j.nlm.2013.04.013. Epub 2013 May 22.

Abstract

Although the requirement for new protein synthesis in synaptic plasticity and memory has been well established, recent genetic, molecular, electrophysiological, and pharmacological studies have broadened our understanding of the translational control mechanisms that are involved in these processes. One of the critical translational control points mediating general and gene-specific translation depends on the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) by four regulatory kinases. Here, we review the literature highlighting the important role for proper translational control via regulation of eIF2α phosphorylation by its kinases in long-lasting synaptic plasticity and long-term memory.

Keywords: GCN2; HRI; Knockout eIF2; PERK; PKR; Synaptic plasticity; Translation initiation; long-term memory.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Eukaryotic Initiation Factor-2 / metabolism
  • Humans
  • Memory, Long-Term / physiology*
  • Mice
  • Neuronal Plasticity / genetics*
  • Phosphorylation
  • Protein Biosynthesis*
  • eIF-2 Kinase / metabolism*

Substances

  • Eukaryotic Initiation Factor-2
  • eIF-2 Kinase