The evolution of the Anopheles 16 genomes project

G3 (Bethesda). 2013 Jul 8;3(7):1191-4. doi: 10.1534/g3.113.006247.


We report the imminent completion of a set of reference genome assemblies for 16 species of Anopheles mosquitoes. In addition to providing a generally useful resource for comparative genomic analyses, these genome sequences will greatly facilitate exploration of the capacity exhibited by some Anopheline mosquito species to serve as vectors for malaria parasites. A community analysis project will commence soon to perform a thorough comparative genomic investigation of these newly sequenced genomes. Completion of this project via the use of short next-generation sequence reads required innovation in both the bioinformatic and laboratory realms, and the resulting knowledge gained could prove useful for genome sequencing projects targeting other unconventional genomes.

Keywords: assembly; collaboration; comparative; malaria; vector.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anopheles / genetics*
  • Base Sequence
  • Biological Evolution*
  • Computational Biology
  • Genome, Insect*
  • Genomics
  • Humans
  • Insect Vectors / genetics
  • Malaria / genetics*
  • Malaria / parasitology
  • Malaria / transmission
  • Sequence Analysis, DNA