SLiM: simulating evolution with selection and linkage

Genetics. 2013 Aug;194(4):1037-9. doi: 10.1534/genetics.113.152181. Epub 2013 May 24.

Abstract

SLiM is an efficient forward population genetic simulation designed for studying the effects of linkage and selection on a chromosome-wide scale. The program can incorporate complex scenarios of demography and population substructure, various models for selection and dominance of new mutations, arbitrary gene structure, and user-defined recombination maps.

Keywords: background selection; genetic hitchhiking; population genetic simulation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Genetic Linkage*
  • Models, Genetic*
  • Mutation
  • Population / genetics
  • Software*