miR-155 is involved in tumor progression of mycosis fungoides

Exp Dermatol. 2013 Jun;22(6):431-3. doi: 10.1111/exd.12161.


Biopsy specimens from 23 early stage and 19 tumor-stage mycosis fungoides (MF) patients were evaluated for miR-155 expression by real-time qualitative PCR and compared with 15 biopsy specimens from patients with T-cell-rich inflammatory skin diseases. Significant upregulation of miR-155 was found in MF tumors compared with both early-stage MF lesions and controls. There was no difference in miR-155 expression between early-stage and inflammatory dermatoses. Using laser capture microdissection, it was found that miR-155 was significantly higher in the lymphoma cells in tumor stage compared with the intraepidermal lymphocytes in early stage. In contrast, there was no difference in miR-155 expression between the intraepidermal lymphocytes and the dermal lymphocytes in early-stage MF. These findings suggest that although miR-155 expression cannot serve to discriminate early-stage MF from inflammatory dermatoses; however, it is involved in the switch from the indolent early stage into the aggressive tumor stage of the disease.

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy
  • Disease Progression
  • Female
  • Gene Expression Regulation*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Inflammation / pathology
  • Laser Capture Microdissection
  • Lymphocytes / metabolism
  • Lymphoma / metabolism
  • Male
  • MicroRNAs / metabolism*
  • Middle Aged
  • Mycosis Fungoides / metabolism*
  • Real-Time Polymerase Chain Reaction
  • Skin / pathology
  • Skin Diseases
  • Skin Neoplasms / metabolism*
  • T-Lymphocytes / cytology
  • T-Lymphocytes / metabolism
  • Up-Regulation


  • MIRN155 microRNA, human
  • MicroRNAs