In vivo minimally invasive interstitial multi-functional microendoscopy

Sci Rep. 2013;3:1805. doi: 10.1038/srep01805.


Developing minimally invasive methodologies for imaging of internal organs is an emerging field in the biomedical examination research. This paper introduces a new multi-functional microendoscope device capable of imaging of internal organs with a minimal invasive intervention. In addition, the developed microendoscope can also be employed as a monitoring device for measuring local hemoglobin concentration in blood stream when administrated into a blood artery. The microendoscope device has a total external diameter of only 200 μm and can provide high imaging resolution capability of more than 5,000 pixels. The device can detect features with a spatial resolution of less than 1 μm. The microendoscope has been tested both in-vitro as well as in-vivo in rats presenting a promising and powerful tool as a high resolution and minimally invasive imaging facility suitable for previously unreachable clinical modalities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / physiology*
  • Chickens
  • Endoscopy*
  • Equipment Design*
  • Extracellular Fluid
  • Green Fluorescent Proteins / metabolism*
  • HEK293 Cells
  • Hemoglobins / analysis*
  • Humans
  • Image Processing, Computer-Assisted
  • Molecular Imaging / methods*
  • Phantoms, Imaging
  • Rats


  • Hemoglobins
  • enhanced green fluorescent protein
  • Green Fluorescent Proteins