Phosphatidylinositol-4-phosphate: the Golgi and beyond

Bioessays. 2013 Jul;35(7):612-22. doi: 10.1002/bies.201200180. Epub 2013 May 27.


Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol-4-phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will discuss selected examples of the findings that in the last few years have significantly increased our awareness of the regulation and roles of PI4P in the Golgi complex and beyond. We will also highlight the role of PI4P in infection and cancer. We believe that, with the increasing number of regulators and effectors of PI4P identified, the time is ripe for a more integrated approach of study. A first step in this direction is the delineation of PI4P-centered molecular networks that we provide using data from low and high throughput studies in yeast and mammals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Golgi Apparatus / metabolism*
  • Humans
  • Mammals / genetics
  • Mammals / metabolism
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Phosphatidylinositol Phosphates / metabolism*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Signal Transduction


  • Phosphatidylinositol Phosphates
  • phosphatidylinositol 4-phosphate