The use of probenecid to increase the serum amoxycillin levels in patients with bronchiectasis

Respir Med. 1990 Mar;84(2):143-6. doi: 10.1016/s0954-6111(08)80018-2.

Abstract

Amoxycillin 3 g twice daily is effective in treating patients with bronchiectasis who have daily purulent sputum. However, it is a relatively expensive treatment if used for prolonged periods. This pilot study in six patients with bronchiectasis showed that the concurrent administration of probenecid with a smaller dose of amoxycillin produced similar clinical responses and pharmacokinetic profiles to those found with high dose amoxycillin alone. The amount of amoxycillin used was reduced by two thirds, producing a potential saving of approximately pound 1000 per patient per annum in those taking long term treatment.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Amoxicillin / administration & dosage
  • Amoxicillin / adverse effects
  • Amoxicillin / pharmacokinetics*
  • Amoxicillin / therapeutic use
  • Bronchiectasis / drug therapy*
  • Bronchiectasis / metabolism
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Probenecid / administration & dosage
  • Probenecid / adverse effects
  • Probenecid / pharmacology*

Substances

  • Amoxicillin
  • Probenecid