Association of a single nucleotide polymorphism in the akirin 2 gene with economically important traits in Korean native cattle

Anim Genet. 2013 Dec;44(6):750-3. doi: 10.1111/age.12055. Epub 2013 May 30.


The akirin 2 gene, located on chromosome 9 in cattle, was previously reported to be associated with nuclear factor-kappa B (NF-κB), involved in immune reactions and marbling of meat. To determine whether a single nucleotide polymorphism (SNP) in akirin 2 is associated with economically important traits of Korean native cattle, the c.*188G>A SNP DNA marker in the 3'-UTR region of akirin 2 was analyzed for its association with carcass weight, longissimus muscle area and marbling. The c.*188G>A SNP was genotyped by polymerase chain reaction restriction fragment length polymorphism, and the frequency of the AA, AG, and GG genotypes were 6.82%, 71.29% and 21.88% respectively. This SNP was significantly associated with longissimus muscle area (Bonferroni corrected P < 0.05), and marbling score (Bonferroni corrected P < 0.01). These results suggest that the c.*188G>A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle.

Keywords: AKIRIN2 gene; longissimus muscle area; marbling score; single nucleotide polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cattle / genetics*
  • Cattle / physiology
  • DNA Primers / genetics
  • Expressed Sequence Tags
  • Gene Frequency
  • Genotype
  • Linear Models
  • Lipids / analysis
  • Lipids / genetics
  • Meat / analysis*
  • Molecular Sequence Data
  • Muscle, Skeletal / chemistry
  • NF-kappa B / genetics
  • Phenotype*
  • Polymorphism, Single Nucleotide / genetics*
  • Quantitative Trait Loci / genetics*
  • Repressor Proteins / genetics*
  • Republic of Korea
  • Sequence Analysis, DNA / veterinary


  • DNA Primers
  • Lipids
  • NF-kappa B
  • Repressor Proteins

Associated data

  • GENBANK/NC007329