Definitive treatment of androgen receptor-positive salivary duct carcinoma with androgen deprivation therapy and external beam radiotherapy

Head Neck. 2014 Jan;36(1):E4-7. doi: 10.1002/hed.23383. Epub 2013 Sep 17.


Background: Salivary duct carcinoma (SDC) is an aggressive malignancy with high recurrence rates. Standard management includes surgical resection followed by adjuvant radiation. Androgen receptor positivity has been described to be present in 40% to 90% of SDCs, and a recent case series showed a benefit to androgen deprivation therapy (ADT) in recurrent or metastatic disease.

Methods and results: We present the case of an 87-year-old woman with a locally advanced androgen receptor-positive parotid SDC treated definitively with ADT and external beam radiotherapy, a regimen modeled after the treatment of prostate cancer. She had a complete response on positron emission tomography (PET)/CT scan and had no evidence of disease 24 months after the completion of treatment.

Conclusion: To our knowledge, this case report is the first to describe the use of ADT plus radiation to definitively treat SDC. This regimen could be considered in patients with androgen receptor-positive SDCs who are considered unresectable or who refuse surgery.

Keywords: androgen deprivation therapy; androgen receptor; radiation; salivary duct carcinoma; salivary gland.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Androgen Antagonists / therapeutic use*
  • Anilides / therapeutic use
  • Biopsy, Needle
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Leuprolide / therapeutic use
  • Magnetic Resonance Imaging / methods
  • Neoplasm Staging
  • Nitriles / therapeutic use
  • Positron-Emission Tomography
  • Radiotherapy, Intensity-Modulated*
  • Receptors, Androgen / metabolism
  • Salivary Gland Neoplasms / diagnosis
  • Salivary Gland Neoplasms / drug therapy*
  • Salivary Gland Neoplasms / radiotherapy*
  • Tosyl Compounds / therapeutic use
  • Treatment Outcome


  • Androgen Antagonists
  • Anilides
  • Nitriles
  • Receptors, Androgen
  • Tosyl Compounds
  • bicalutamide
  • Leuprolide