Post-staphylococcal infection Henoch-Schönlein purpura nephritis: a case report and review of the literature

Ren Fail. 2013 Jul;35(6):869-74. doi: 10.3109/0886022X.2013.794703. Epub 2013 May 30.


A 37-year-old man developed Henoch--Schönlein purpura nephritis (HSPN) with nephrotic syndrome and rapidly progressive glomerulonephritis after otitis media and externa due to methicillin-resistant Staphylococcus aureus infection. Despite resolution of the infection and prednisolone therapy, his kidney disease worsened. However, the addition of cyclosporine A finally resulted in complete remission of the nephrotic syndrome. A review of similar cases with post-Staphylococcal infection HSPN revealed strong similarities between this entity and immunoglobulin A-dominant postinfectious glomerulonephritis (IgA-PIGN), an increasingly recognized form of PIGN typically associated with Staphylococcal infection, in both clinical and morphological features. Post-Staphylococcal infection HSPN may constitute a subgroup of IgA-PIGN.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Cyclosporine / therapeutic use
  • Glomerulonephritis / drug therapy
  • Glomerulonephritis / etiology*
  • Glomerulonephritis / microbiology
  • Glucocorticoids / therapeutic use
  • Humans
  • IgA Vasculitis / complications*
  • IgA Vasculitis / microbiology
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Methicillin-Resistant Staphylococcus aureus*
  • Prednisolone / therapeutic use
  • Staphylococcal Infections / complications*
  • Staphylococcal Infections / microbiology


  • Glucocorticoids
  • Immunosuppressive Agents
  • Cyclosporine
  • Prednisolone