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, 10 (6), 508-13

CLARITY for Mapping the Nervous System


CLARITY for Mapping the Nervous System

Kwanghun Chung et al. Nat Methods.

Erratum in

  • Nat Methods. 2013 Oct;10(10):1035


With potential relevance for brain-mapping work, hydrogel-based structures can now be built from within biological tissue to allow subsequent removal of lipids without mechanical disassembly of the tissue. This process creates a tissue-hydrogel hybrid that is physically stable, that preserves fine structure, proteins and nucleic acids, and that is permeable to both visible-spectrum photons and exogenous macromolecules. Here we highlight relevant challenges and opportunities of this approach, especially with regard to integration with complementary methodologies for brain-mapping studies.

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