The Effect of Soybean-Derived Phosphatidylserine on Cognitive Performance in Elderly With Subjective Memory Complaints: A Pilot Study

Clin Interv Aging. 2013;8:557-63. doi: 10.2147/CIA.S40348. Epub 2013 May 21.

Abstract

Objective: To evaluate the efficacy and safety of soybean-derived phosphatidylserine (SB-PS) (300 mg/day) in improving cognitive performance in elderly with memory complaints, following a short duration of 12 weeks' SB-PS administration.

Methods: SB-PS was administered daily for 12 weeks to 30 elderly volunteers with memory complaints (age range 50-90 years). Cognitive performance was determined by a computerized test battery and by the Rey Auditory Verbal Learning Test (Rey-AVLT). Physical examination and blood safety parameters were part of the extensive safety analysis of PS that was performed.

Results: The computerized test results showed that SB-PS supplementation significantly increased the following cognitive parameters: memory recognition (P = 0.004), memory recall (P = 0.006), executive functions (P = 0.004), and mental flexibility (P = 0.01). The Rey-AVLT indicated that, following SB-PS administration, total learning and immediate recall improved significantly (P = 0.013 and P = 0.007, respectively). Unexpected results from the safety tests suggested that SB-PS significantly reduces both systolic (P = 0.043) and diastolic (P = 0.003) blood pressure. SB-PS consumption was well tolerated and no serious adverse events were reported during the study.

Conclusion: This exploratory study demonstrates that SB-PS may have favorable effects on cognitive function in elderly with memory complaints. In addition, the study suggests that SB-PS is safe for human consumption and may serve as a safe alternative to phosphatidylserine extracted from bovine cortex. These results encourage further extended studies in order to establish the safety and efficacy of SB-PS treatment.

Keywords: AAMI; cognitive; learning; memory; phosphatidylserine.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Female
  • Geriatric Assessment
  • Humans
  • Male
  • Memory Disorders / drug therapy*
  • Middle Aged
  • Neuropsychological Tests
  • Phosphatidylserines / therapeutic use*
  • Pilot Projects
  • Soybeans / chemistry*
  • Statistics, Nonparametric
  • Treatment Outcome

Substances

  • Phosphatidylserines