Dentin hypersensitivity after teeth bleaching with in-office systems. Randomized clinical trial

Am J Dent. 2013 Feb;26(1):10-4.


Purpose: To comparatively and prospectively compare in a randomized clinical trial, dentin hypersensitivity after treatment with three in-office bleaching systems, based on hydrogen peroxide at different concentrations, with and without light source activation.

Methods: 88 individuals were included according to inclusion and exclusion criteria. Subjects were randomly divided into the following three treatment groups: Group 1 was treated with three 15-minute applications of hydrogen peroxide at 15% with titanium dioxide (Lase Peroxide Lite) that was light-activated (Light Plus Whitening Lase) with five cycles of 1 minute and 30 seconds each cycle, giving a total treatment time of 45 minutes; Group 2 was treated with three 10-minute applications of hydrogen peroxide at 35% (Lase Peroxide Sensy), activated by light (LPWL) same activation cycles than Group 1, with a total treatment time of 30 minutes; Group 3 was treated with only one application for 45 minutes of hydrogen peroxide at 35% (Whitegold Office) without light activation. Each subject underwent one session of bleaching on the anterior teeth according to the manufacturers' instructions. Dentin sensitivity was recorded with a visual analogue scale (VAS) at baseline, immediately after, and at 7 and 30 days after treatment using a stimulus of an evaporative blowing triple syringe for 3 seconds on the upper central incisors from a distance of 1 cm. A Kruskal-Wallis test followed by Mann-Whitney test was performed for statistical analysis.

Results: All groups showed increased sensitivity immediately after treatment. Group 1 displayed less changes relative to baseline with no significant differences (P = 0.104). At 7 and 30 days after treatment, a comparison of VAS values indicated no significant differences between all groups (P = 0.598 and 0.489, respectively).

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Dentin Sensitivity / etiology*
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Hydrogen Peroxide / administration & dosage
  • Hydrogen Peroxide / therapeutic use*
  • Lasers, Semiconductor / therapeutic use
  • Male
  • Pain Measurement
  • Photochemotherapy / methods
  • Photosensitizing Agents / therapeutic use
  • Phototherapy / methods
  • Prospective Studies
  • Time Factors
  • Titanium / therapeutic use
  • Tooth Bleaching / methods*
  • Tooth Bleaching Agents / administration & dosage
  • Tooth Bleaching Agents / therapeutic use*
  • Young Adult


  • Photosensitizing Agents
  • Tooth Bleaching Agents
  • titanium dioxide
  • Hydrogen Peroxide
  • Titanium