Hypnosis versus diazepam for embryo transfer: a randomized controlled study

Am J Clin Hypn. 2013 Apr;55(4):378-86. doi: 10.1080/00029157.2012.747949.


Levitas et al. (2006) showed in a cohort study that hypnosis during embryo transfer (ET) increased pregnancy ratio by 76%. In order to evaluate hypnosis during ET in a general population, the authors performed a randomized prospective controlled study comparing diazepam (usual premedication) administered before ET plus muscle relaxation versus hypnosis plus placebo in 94 patients. Additionally, the authors studied anxiety pre and post ET. Anxiety scores were not different in the two groups before and after ET. No difference in pregnancy and birth ratio was found in the two groups. Hypnosis during ET is as effective as diazepam in terms of pregnancy ratio and anxiolytic effects, but with fewer side effects and should be routinely available.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Anti-Anxiety Agents / administration & dosage*
  • Anxiety* / diagnosis
  • Anxiety* / drug therapy
  • Birth Rate
  • Diazepam / administration & dosage*
  • Embryo Transfer / methods*
  • Female
  • Humans
  • Hypnosis / methods*
  • Placebos
  • Pregnancy
  • Pregnancy Rate
  • Prospective Studies
  • Surveys and Questionnaires
  • Treatment Outcome
  • Young Adult


  • Anti-Anxiety Agents
  • Placebos
  • Diazepam